Pump the brakes: how science is slowing down premature ejaculation (2024)

Sex isn’t just a biological act, it’s a cornerstone of human connection, culture, and health. It inspires poetry, laws, and even scientific exploration. Beyond reproduction, sex can lift your mood, ease stress, and even protect your heart. Frequent ejaculations may even reduce the risk of prostate cancer—a fact that brings a smile to any urologist’s face.

Ejaculation is a finely tuned process with two main stages. The first, emission, gathers seminal fluid and ensures it flows correctly, while the second, expulsion, relies on rhythmic muscle contractions to complete the process. These contractions often lead to the pinnacle of pleasure, known as orgasm. However, when this process speeds up too much, it can result in premature ejaculation (PE), the most common male sexual issue.

A widespread yet

underrated problemPE affects millions of men, with prevalence rates as high as 75 percent in some studies. These numbers depend on how PE is defined and the cultural attitudes toward seeking help for it. Broadly, PE occurs when a man ejaculates too quickly—often within a minute of penetration—and feels distressed about it.

This isn’t just about timing. PE can harm relationships, making intimacy stressful instead of enjoyable. Many men with PE experience feelings of embarrassment, frustration, or guilt. Over time, these feelings may lead to avoidance of intimacy altogether, creating a downward spiral of anxiety and depression.

What causes PE?

While psychological factors like stress, anxiety, and low self-esteem play a big role, PE is now understood to have more complex origins. Biological factors are just as important. Low levels of serotonin, a brain chemical tied to mood and desire, are strongly linked to shorter ejaculation times. Hormonal imbalances, such as low testosterone or an overactive thyroid, can also contribute.

Additionally, certain health conditions—like diabetes, erectile dysfunction, or prostate inflammation—can make PE more likely. Even genetics, recreational drug use, and alcohol can play a role in triggering or worsening the condition.

Recent research has uncovered even deeper insights into what causes PE, offering new hope for better treatments.

Fresh findings

Scientists are discovering that the nervous system’s role in PE is more complex than previously thought. A leading theory points to sympathovagal imbalance—an overactive sympathetic nervous system paired with insufficient parasympathetic activity. The sympathetic nervous system is responsible for the “fight or flight” response, which can work against the calming effects of the parasympathetic system needed for ejaculatory control.

Men with PE often show signs of heightened sympathetic activity, even when not aroused. Their heart rate recovery after stress tests is slower than normal, further indicating this imbalance. This suggests that PE may partly stem from issues in the body’s nervous system.

Another surprising discovery involves leptin, a hormone most commonly associated with regulating energy and appetite. Men with PE have been found to have higher levels of leptin than men without the condition. These levels tend to decrease significantly after treatment with selective serotonin reuptake inhibitors (SSRIs). This suggests leptin may play a role in regulating neurotransmitters, such as serotonin, which are critical for ejaculatory control.

Finally, disruptions in serotonin remain central to understanding PE. Men with low serotonin levels, or reduced sensitivity to this neurotransmitter, often have shorter intravaginal ejaculatory latency times (IELT). These findings highlight the need for a more comprehensive diagnostic framework that accounts for hormonal, autonomic, and neurochemical factors.

The impact of PE

The consequences of PE go beyond the bedroom. Men with PE often experience low self-esteem, strained relationships, and a reduced quality of life. Their partners may feel frustrated or unsatisfied, which can lead to tension and even the breakdown of relationships. For many men, the condition becomes a source of shame, preventing them from seeking help.

This is why treating PE effectively is about more than physical symptoms—it’s about restoring confidence, intimacy, and well-being.

Emerging treatment options

Thanks to new research, a range of innovative treatments is reshaping how PE is managed. While traditional methods like SSRIs and topical anaesthetics remain helpful, they often come with limitations. Newer treatments offer more targeted, effective, and patient-friendly solutions.

Exercise therapy

Exercise is proving to be a simple yet powerful tool in managing PE. A two-week high-intensity interval training (HIIT) program showed remarkable results in men with PE. This exercise routine helped reduce sympathetic over activity, improving the balance between the nervous system’s “go” and “calm” responses.

Beyond its physical benefits, HIIT boosted participants’ self-esteem and body image, creating a positive feedback loop that further enhanced their sexual satisfaction.

Leptin-based treatments

The discovery of leptin’s role in PE has opened exciting new doors. Targeting leptin could help regulate ejaculation, especially since decreasing its levels has shown promise in extending IELT. Leptin could also become a reliable diagnostic tool, making it easier for healthcare providers to identify and manage PE effectively.

Strengthening pelvic

floor musclesPelvic floor muscles play a key role in ejaculation. Weak muscles can lead to poor control, while stronger ones can significantly improve it. Neuromuscular electrical stimulation (NMES) uses electrical impulses to strengthen these muscles, often combined with physiotherapy and biofeedback techniques.

Studies show that NMES programs can increase IELT and provide long-term benefits. While these programs require dedication over weeks, the results can be life-changing for men with lifelong PE.

On-demand solutions

For men looking for immediate solutions, devices like transcutaneous electrical nerve stimulation (TENS) patches are becoming game-changers. These patches stimulate key muscles during sexual activity, delaying ejaculation.

TENS is non-invasive, drug-free, and easy to use, making it a promising alternative for men who prefer not to rely on medication or invasive treatments.

Combining approaches

Behavioural therapies have long been used to treat PE, teaching men strategies to delay ejaculation. When combined with technologies like TENS or NMES, these therapies can offer even better results. By addressing both the psychological and physiological aspects of PE, this comprehensive approach ensures long-term improvements.

A multifaceted approach to treatment

Treating PE is rarely a one-size-fits-all process. Every man is different, and so is every case of PE. That’s why a multimodal approach—combining physical, psychological, and technological treatments—is often the best way forward.

Looking ahead

The future of PE treatment is bright. Advances in understanding the condition are paving the way for more personalized and effective solutions. From managing autonomic imbalances to leveraging the latest technologies, the options for men with PE are growing.

As newer treatments become available, the stigma around PE may finally start to lift. More men will feel comfortable seeking help, knowing that real solutions are within reach.

Restoring confidence

PE is more than a physical condition, it’s a barrier to intimacy, self-esteem, and happiness. Addressing it isn’t just about fixing a problem; it’s about helping men reclaim a vital part of their lives.

Sex is about more than reproduction or pleasure. It’s a fundamental part of who we are. By advancing our understanding of PE and developing better treatments, we’re not just improving physical health—we’re transforming lives.

• Dr. Greggory Pinto is a board certified Bahamian Urologist and Laparoscopic Surgeon. Dr. Pinto can be contacted at OakTree Medical Center #2 Fifth Terrace and Mount Royal Avenue, Nassau, Bahamas. Telephone: (242) 322-1145(6)(7) Email: welcome@urologycarebahamas.com or visit the website:www.urologycarebahamas.com.

Pump the brakes: how science is slowing down premature ejaculation (2024)
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