Monocyte function in familial Mediterranean fever (2025)

Abstract

Monocytes derived from the peripheral blood of patients with familial Mediterranean fever (FMF) demonstrated a consistently lower phagocytic capacity (38-44%) for 125I-labelled Shigella flexneri when compared to monocytes from healthy subjects. Phagocytosis of both viable and killed Staphylococcus albus was similar in patients and controls. However, FMF monocytes had a two- to eight-fold depressed bactericidal capacity against S. albus in comparison to normal monocytes. Acid phosphatase and β-glucuronidase monocyte activities were similar in patients and controls. It is suggested that the defects in monocyte function may be of importance in the pathogenesis of FMF. Colchicine had no effect on any of the indices studied.

Original languageEnglish
Pages (from-to)265-270
Number of pages6
JournalAmerican Journal of the Medical Sciences
Volume274
Issue number3
DOIs
StatePublished - 1977

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Bar-Eli, M., Gallily, R., Levy, M., & Eliakim, M. (1977). Monocyte function in familial Mediterranean fever. American Journal of the Medical Sciences, 274(3), 265-270. https://doi.org/10.1097/00000441-197711000-00004

Bar-Eli, M. ; Gallily, R. ; Levy, M. et al. / Monocyte function in familial Mediterranean fever. In: American Journal of the Medical Sciences. 1977 ; Vol. 274, No. 3. pp. 265-270.

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title = "Monocyte function in familial Mediterranean fever",

abstract = "Monocytes derived from the peripheral blood of patients with familial Mediterranean fever (FMF) demonstrated a consistently lower phagocytic capacity (38-44%) for 125I-labelled Shigella flexneri when compared to monocytes from healthy subjects. Phagocytosis of both viable and killed Staphylococcus albus was similar in patients and controls. However, FMF monocytes had a two- to eight-fold depressed bactericidal capacity against S. albus in comparison to normal monocytes. Acid phosphatase and β-glucuronidase monocyte activities were similar in patients and controls. It is suggested that the defects in monocyte function may be of importance in the pathogenesis of FMF. Colchicine had no effect on any of the indices studied.",

author = "M. Bar-Eli and R. Gallily and M. Levy and M. Eliakim",

year = "1977",

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Bar-Eli, M, Gallily, R, Levy, M & Eliakim, M 1977, 'Monocyte function in familial Mediterranean fever', American Journal of the Medical Sciences, vol. 274, no. 3, pp. 265-270. https://doi.org/10.1097/00000441-197711000-00004

Monocyte function in familial Mediterranean fever. / Bar-Eli, M.; Gallily, R.; Levy, M. et al.
In: American Journal of the Medical Sciences, Vol. 274, No. 3, 1977, p. 265-270.

Research output: Contribution to journalArticlepeer-review

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T1 - Monocyte function in familial Mediterranean fever

AU - Bar-Eli, M.

AU - Gallily, R.

AU - Levy, M.

AU - Eliakim, M.

PY - 1977

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N2 - Monocytes derived from the peripheral blood of patients with familial Mediterranean fever (FMF) demonstrated a consistently lower phagocytic capacity (38-44%) for 125I-labelled Shigella flexneri when compared to monocytes from healthy subjects. Phagocytosis of both viable and killed Staphylococcus albus was similar in patients and controls. However, FMF monocytes had a two- to eight-fold depressed bactericidal capacity against S. albus in comparison to normal monocytes. Acid phosphatase and β-glucuronidase monocyte activities were similar in patients and controls. It is suggested that the defects in monocyte function may be of importance in the pathogenesis of FMF. Colchicine had no effect on any of the indices studied.

AB - Monocytes derived from the peripheral blood of patients with familial Mediterranean fever (FMF) demonstrated a consistently lower phagocytic capacity (38-44%) for 125I-labelled Shigella flexneri when compared to monocytes from healthy subjects. Phagocytosis of both viable and killed Staphylococcus albus was similar in patients and controls. However, FMF monocytes had a two- to eight-fold depressed bactericidal capacity against S. albus in comparison to normal monocytes. Acid phosphatase and β-glucuronidase monocyte activities were similar in patients and controls. It is suggested that the defects in monocyte function may be of importance in the pathogenesis of FMF. Colchicine had no effect on any of the indices studied.

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Bar-Eli M, Gallily R, Levy M, Eliakim M. Monocyte function in familial Mediterranean fever. American Journal of the Medical Sciences. 1977;274(3):265-270. doi: 10.1097/00000441-197711000-00004

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